October — Obesity has long been associated with lifestyle factors such as diet and exercise, but new research shows that genetics also play a significant role. A groundbreaking study published in Nature Communications has identified 13 genes linked to obesity, five of which have never been reported before.
The international research team analyzed genetic data from 850,000 individuals across six continents, making it one of the largest studies of its kind. While eight of the genes had been highlighted in earlier studies, the newly identified ones — YLPM1, RIF1, GIGYF1, SLC5A3, and GRM7 — open new avenues for understanding how obesity develops.
Scientists emphasized that obesity is a complex condition, influenced by both environment and biology. While lifestyle choices remain important, these findings confirm that genetic predisposition can significantly increase the risk of weight gain.
Obesity is a major global health challenge, raising the likelihood of type 2 diabetes, heart disease, and osteoarthritis. By pinpointing these genes, researchers believe the study could pave the way for more effective, targeted medicines. Importantly, the study’s global scope ensures that the results are not limited to one ancestry group, addressing a long-standing gap in obesity research.
Lead researchers noted that the discovery highlights the importance of cross-ancestry studies, which can reveal genetic factors overlooked in population-specific research. This broader approach may help design treatments that are effective across diverse populations.
The findings also reinforce the idea that obesity should not be seen solely as the result of personal choices. Instead, it is a multifaceted condition shaped by both lifestyle and biology, requiring equally nuanced solutions.